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脂质体药物及其靶向治疗恶性脑肿瘤的研究进展 被引量：2

Study Progress of Liposome and Its Target Treatment of malignant
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摘要 化疗是恶性颅内肿瘤综合治疗中的重要环节。本文围绕脂质体的特性及抗癌药物脂质体在化疗中研究和应用,对其透过血脑屏障,减少毒副作用以及联合化疗的靶向性等方面的研究进展进行综述。 Chemotherapeutics is one of the significant process in treatment of malignant brain turnout , this article reported the special feature of liposome , in addition , expatiates investigation and applications of liposomal antineoplastic agents in chemotherapeutics , the strategies for crossing the brain blood barrier （BBB） and reducing toxicity and being target therapeutic agents to malignant brain tumors were reviewed.
作者 马满玲 张旭 高建华
机构地区 哈尔滨医科大学第一临床医学院 哈尔滨伊达药业有限公司
出处 《中国伤残医学》 2008年第1期110-111,共2页 Chinese Journal of Trauma and Disability Medicine
关键词 脂质体 治疗 恶性脑肿瘤 血脑屏障 Liposome Chemotherapeutics Malignant brain tumour Brain blood barrier （BBB）
分类号 R739.41 [医药卫生—肿瘤]
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参考文献13

  • 1[2]C.Tardi et al.Steam sterilisation of vesicular phospholipid gels[J].International Journal of Pharmaceutics 217 (2001) 161-172.
  • 2[3]Park J W,Kirpotin D,et al.Immunoliposomes for cancer treatment[J].Adv Pharmacol,1997,40:399.
  • 3[4]M.Brandl et al.Lipsome preparation by a new high pressure homogenizer gaulin micro lab[J].40 Drug development and Industrial pharmacy.1997,16(14) 2167-2197.
  • 4[5]Wei Liang,Tatyana Levchenko,Ban-An Khaw and Vladimir Torchilin ATP-Containing Immunoliposomes[J].Specific for Cardiac Myosin Current Drug Delivery(2004)1(1),1-7.
  • 5[6]Ruel-Gariepy E,et al.Thermosensitive chitosan-based hydrogel containing liposomes for the delivery of hydrophilic molecules[J].J Control Release.2002 Aug 21;82(2-3):373-83.
  • 6[7]Li W,Huang Z,et al.Low-pH-sensitive poly(ethylene glycol) (PEG)-stabilized plasmid nanolipoparticles:effects of PEG chain length,lipid composition and assembly conditions on gene delivery[J].Gene Med.2005 Jan;7(1):67-79.
  • 7[8]FournierE,PassiranC,Montero-MeneiC,et al.Therapeutic effectiveness novel 5-fluorouracil-loapdeddy-based microspheres on F98 glioma-bearing rats[J].Cancer,2003 ;97 (11):2822-2829.
  • 8[9]M.Glavas-Dodov et al.:5-Fluorouracil in topical liposome gels for anticancer treatment-Formulation and evaluation[J].Acta Pharm.53 (2003) 241-250.
  • 9[10]Liu JJ,Hong RL,Cheng WF,et al.Simple and efficient liposomel encapsulation of topotecan by ammonium sulfate gradient:stability,pharmacyokinetic and therapeuticc evaluation[J].Anticancer Drugs,2002,13(7):709-717.
  • 10[11]Pardridge W M.Drug and gene targeting to the brain with trojan horses[J].Nat Rev Drug Discov,2000,1(2):131-139.

同被引文献16

  • 1董兰凤,赵兴茹,冯凤莲,范美菊,杨丽.阿霉素长循环热敏脂质体的研制及其靶向治疗肿瘤作用的研究[J].中国肿瘤生物治疗杂志,2005,12(1):52-56. 被引量：8
  • 2陆彬.脂质体、修饰脂质体与改良脂质体给药系统及其进展(上)[J].中国药师,2005,8(5):374-377. 被引量：9
  • 3KOUDELKA S, TURANEK J. Liposomal paclitaxel formulations [ J ]. Control Release, 2012, 163 ( 3 ) : 322 - 334.
  • 4KANG M J, PARK S H, KANG M H, et al. Folic acid-tethered Pep-1 peptide-conjugated liposomal aanocarrier for enhanced intracellular drug delivery to :ancer cells: conformational characterization and in itro cellular uptake evaluation [J]. Nanomedicine,2012,8(3) :1155 - 1165.
  • 5KASTANTIN M, ANANTHANARAYANAN B, KARMALI P, et al. Effect of the lipid chain melting transition on the stability of DSPE-PEG 2000micelles [J]. Langmuir,2009,25 ( 13 ) :7279 - 7286.
  • 6GIUSEPPE M, FRANCOIS L. Design and synthesis of N-maleimido functionalized hydrophilic polymers via copper-mediated living radical polymerization:A suit- able alternative to PEGylation chemistry [ J ]. Am Chem Soc ,2005,127 ( 9 ) :2966 - 2973.
  • 7LIANG C, LEE D W, NEWTON M G, et al. Synthesis of L-dioxolane nucleosides and related chemistry [J ] Org Chem,1995,60(6):1546- 1553.
  • 8BODEN N, BUSHBY R J, LIU Q, et al. N, N'-Disuc- cinimidyl carbonate as a coupling agent in the synthe- sis of thiophospholipids used for anchoring biomem- branes to gold surfaces [J]. Tetrahedron, 1998, 54 (38) :1537 - 1548.
  • 9李津明,张彦卓,李鑫.依托泊苷长循环脂质体工艺处方设计与优化的研究[J].安徽医药,2008,12(6):488-491. 被引量：8
  • 10杨志勇,季艳霞,李书芹,刘峥.紫杉醇脂质体与紫杉醇治疗62例非小细胞肺癌的疗效分析[J].中国肿瘤,2008,17(8):717-719. 被引量：4

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中国伤残医学
2008年 第1期

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