摘要
目的探讨垂体瘤转化基因(PTTG),碱性成纤维细胞生长因子(bFGF)及血管内皮生长因子(VFGF)在子宫内膜异位症中表达及意义。方法应用免疫组织化学技术,检测48例子宫内膜异位症及30例正常子宫内膜组织中PTTG、bFGF及VEGF的表达水平。结果在子宫内膜异位症中,PT-TG、bFGF及VEGF的阳性表达率分别是81.2%、77.1%及66.7%,其阳性率及表达等级均明显高于正常子宫内膜组织(P<0.01)。三者均呈正相关关系。结论子宫内膜异位症中PTTG的表达明显高于正常子宫内膜组织,而高表达的PTTG可刺激bFGF和VEGF的表达,三者共同促使子宫内膜异位症的发展。
Objective To dissass PTTG ,bFGF and VEGF the expression and significance in the Endometriosis. Methods By means of immunohistochemistry,to test the PTTG、bFGF and VEGF expression level in 48 cases of Endometriosis and 30 cases of Normal endometrium tissue. Results In Endometriosis PTTG,bFGF and VEGF expression rate was 81.2% 、77.1% and 66.7%. The masculine rate and the expression rank were obviously higher than normal endometrium organization（ P 〈 0.01 ）. The three indexes were positively correlated each other. Conclusion The expression of PTTG in endometriosis was significantly higher than that in Normal endometrium. The high expression of PTTG can stimulate the expression of bFGF and VEGF. The three substanles can make the development of Endometriosis together.
出处
《中国实用医药》
2008年第9期5-6,共2页
China Practical Medicine
