短疗程适形非常规放疗同步EP方案化疗Ⅲ期非小细胞肺癌68例

Synchro EP of extraordinary gauge of short course of treatment shape suitable radiotherapy scheme chemotherapy Ⅲ in non-cellule lung cancer phase of 68 cases

目的探讨非小细胞肺癌(NSCLC)短疗程适形非常规放疗同步EP方案化疗的疗效。方法Ⅲ期NSCLC患者68例,第1周采用适形常规放疗,2GY/次,照射5次,周六、日休息;然后采用常规大剂量放疗3GY/次,5次/周,照射10次;第4周与第1周治疗方式相同;第5周3GY/次,照射3次;共31d完成全部放疗,等效生物剂量为70GY。化疗采用EP方案:第1、2、3天VP-1680mg/m2,静脉滴注;第1天PDD60mg/m2静脉滴注。21d为1个周期,于照射当天同时行静脉化疗。同步放化疗结束后第3周再行3周期强化静脉化疗。结果近期有效率为89.7%,1、2、3年生存率为73.5%、39.7%、22.1%;中位生存期为19.6个月。结论短疗程适形非常规放疗同步EP方案化疗Ⅲ期NSCLC有较好疗效,不良反应可以耐受。

Objective Explore the treatment effect of non-cellule lung cancer（NSCLC） owes a course of treatment the synchro EP of extraordinary shape gauge suitable radiotherapy scheme chemotherapy. Methods Ⅲ expects the NSCLC patients of 68 cases ,the first cycles adopted the shape routine radiotherapy suitable ,2 GY/irradiate 5 times, gradually have a rest Saturday, Adopt large dosages of routine then radiotherapy 3 GY/are inferior,5 times off/cycles,irradiate 10 times;The fourth cycles and the first cycles were treated is identical;the Fifth cycle 3 GY/irradlate 3 times ,31 days accomplishes all radiotherapies ,equivalent living things dosages are 70 GY. The chemotherapy adopt the EP scheme：VP-16 80 mg/m2 quiescent point the 1 st,2nd,3nd day; PDD 60 mg/m2 quiescent point 1 st day. 21 days is a period ,in irradiating the very day performing the vein chemotherapy at the same time. Put in a chemotherapy synchroly 3 periods ending last third strengthen the vein chemotherapy. Results The efficiency in the near future is 89.7% ,the survival rate is 73.5% ,39.7% ,22. 1% for1,2,3 years respectivelly; The median place life cycle is 19.6 months. Conclusion Synchro EP of extraordinary gauge of short course of treatment shape suitable radiotherapy scheme chemotherapy Ⅲ scheduled time NSCLC has the fairly treatment effect ,The patient could endure the side-effects.