震颤麻痹的立体定向放射治疗

Stereotactic locating radiotherapy for paralysis agitans

目的探讨立体定向放射治疗震颤麻痹的方法、疗效。方法26例震颤麻痹患者均经CT、MRI扫描，立体定向靶点定位、6mVX线照射；靶点数2个，边周剂量90～100Gy，准直器5mm，实施单次、非共面、多角度的旋转照射治疗。结果随访1～24个月，依据症状改善情况判定疗效．1个月显效6例，占23％；1～3个月有效16例，占62％；无效4例．占15％；总有效率达85％（22／26）。6个月内症状改善者未再出现复发或加重现象。放疗后出现面部疱疹、恶心、头胀痛及暂时肢体无力，经对症处理后症状好转。结论立体定向放射治疗中老年震颤麻痹是一种无刨伤、安全有效的治疗方法。

Objective To discuss the method and curative effect of stereotactic radiotherapy（SRT） for paralysis agitans. Methods Twenty-six patients with paralysis agitans were scaned by CT or MRI, oriented by stereotaetie target and radiated by 6 mV X-ray. The patients received 2 target regions, peripheral dose of 90～100 Gy and 5 mm collimator. Thirty patients were treated with noncoplanarity fractional, once and multiangular stereotactic radiotherapy. Results The follow-up period ranged from 1 to 24 months. The curative effect was determined according to symptom improving. Twenty patients received a marked effect in a month. The effect rate reached 23 %. The effect rate of 16 effectual was 62%. Four patients＇ treatment effects were only 15 %. The total effect rate reached 85%（22/26）. The patients with symptom improving didn＇t relapse and aggravate any more within 6 months. There were some symptom such as herpes in the face, queasiness, headache, limp temporarily after radiotherapy, hut it would he improved after dealing with. Conclusion SRT will he a safe treating method without wound for middle and old age patients with paralysis agitans.