健脾疏肝法治疗葡萄糖耐量减低24例疗效观察

Clinical Observation of Method of Spleen Fortifying and Liver Soothing for 24 Cases of Impaired Glucose Tolerance

目的：以中医中药健脾疏肝法治疗葡萄糖耐量减低（IGT）,以期减少其转化为糖尿病的危险。方法：将确诊为葡萄糖耐量减低的患者随机分为生活干预组（干预组）22例、中药加二甲双胍组（中西药组）24例、二甲双胍组（西药组）20例,3组患者均给予生活干预,而中西药组给于口服健脾消糖颗粒及盐酸二甲双胍,西药组给于盐酸二甲双胍,3个月为1个疗程,观察其临床效果及对血糖、血脂的影响。结果：治疗前后比较,3组空腹血糖及餐后血糖水平均有下降（P〈0.05-P〈0.001）,中西药组及西药组空腹血糖、餐后血糖下降较为明显（P〈0.001）;3组患者治疗前后TG、TC变化比较,干预组TG、TC水平下降不明显（P〈0.1）;而中西药组TG、TC降低较为明显（P〈0.05-P〈0.001）;西药组TG下降不明显（P〈0.1）,TC降低较为明显（P〈0.05）。结论：通过生活干预、服用健脾消糖颗粒及盐酸二甲双胍均可改善IGT患者的血糖水平;中药健脾消糖颗粒能够改善空腹、餐后血糖水平及血脂水平,可以有效的治疗IGT。

Objective：to treat Impaired Glucose Tolerance （IGT） with the Chinese medical method of spleen fortifying and liver soothing to reduce risk of conversion to diabetes. Methods：Confirmed IGT subjects were randomly grouped to the lifestyle intervention group （22 cases）, the integrative group （take Spleen Fortifying and Blood Reduction Granules orally plus deltamine, 24 cases）, and the biomedicine group （with deltamine, 20 cases）. All subjects were intervened in life style. After one period of treatment （3 months）, blood sugar and blood fat of respective groups were observed. Results：FPG and 2hPG levels of all groups were lowered （P 〈 0.05 -0. 001 ） after treatment, and the tendency were more significant of the integrative group and biomedicine group （P 〈 0. 001 ）. Drop of TG and TC levels were inconspicuous of the intervention group （ P 〈 0. 1 ）, but marked of the integrative group （ P 〈 0. 05 - P 〈 0. 001 ）. TG level dropped mildly （P 〈 0. 1 ）, while TC level was significantly down （P 〈 0.05 ） of the biomedicine group. Conclusion：life style intervention, Spleen Fortifying and Blood Reduction Granules and deltamine can lower BS level of IGT patients. In particular the granule was able to improve levels of fasting plasma glucose, postprandial blood sugar and blood fat in the way to effectively cure IGT disease.