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CXCR4在肿瘤中的研究进展 被引量：6

Research progress about CXCR4 and tumor
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摘要 CXCR4是一个由352个氨基酸构成的视紫红质样G蛋白偶联受体,趋化因子CXCL12是该受体的唯一配体。目前发现CXCR4在23种不同类型肿瘤中均有表达,并且在肿瘤细胞增殖、浸润、血管新生及转移过程中起到非常重要的作用。针对CXCR4靶向治疗将成为肿瘤基因治疗研究的新热点。 CXCR4 is a 352 amino acid rhodopsin-like G protein-coupled receptor and CXCL12 is the only ligland for CXCR4.At present,malignant cells from 23 different types of cancer express CXCR4,plays an important role in tumor proliferation,infiltration,vascularization and metastasis.CXCR4-targeted therapeutic approaches will become a new hot point in the research of tumor gene therapy.
作者 卢春来 葛棣
机构地区 复旦大学附属中山医院胸外科
出处 《复旦学报（医学版）》 CAS CSCD 北大核心 2008年第2期311-313,318,共4页 Fudan University Journal of Medical Sciences
关键词 趋化因子受体 肿瘤 CXCR4 chemokine receptor tumor CXCR4
分类号 R730 [医药卫生—肿瘤]
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参考文献32

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同被引文献51

  • 1郑正荣,杨春康,戴起宝.趋化因子受体对肿瘤生物学行为的影响[J].世界华人消化杂志,2006,14(5):513-518. 被引量：7
  • 2徐萌,李五一,陈新明,王新红,黄静,王丽.口腔鳞癌中趋化因子受体CXCR4的临床病理及细胞学研究[J].中华口腔医学杂志,2006,41(6):372-375. 被引量：5
  • 3马向涛,余力伟,王杉,杜如昱,崔志荣.趋化因子受体CXCR4/CXCL12信号转导通路与胃癌淋巴结转移关系的研究[J].中国肿瘤临床,2007,34(10):544-546. 被引量：19
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  • 8HUANG Y C,HSIAO Y C,CHEN Y J,et al.Stromal cell-derived factor-1 enhances motility and integrin up-regulation through CXCR4,ERK and NF-kappaB-dependent pathway in human lung cancer cells[J].Biochem Pharmacol,2007,74(12):1702-1712.
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  • 10YASUMOTO K,KOIZUMI K,KAWASHIMA A,et al.Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer[J].Cancer Res,2006,66(4):2181-2187.

引证文献6

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复旦学报（医学版）
2008年 第2期

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