N-(2-(2-Methoxyphenylthio)benzyl)-2-aryloxyethylamines:Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities 被引量：1

N-(2-(2-Methoxyphenylthio)benzyl)-2-aryloxyethylamines:Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities

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摘要 The design, synthesis and biological evaluation of N-（2-（2-methoxyphenylthio） benzyl）-2-aryloxyethyl amines with dual 5-HT1A/SSR/activities are reported. Compound 8e displays the best dual activities and is a promising lead compound for further SAR studies. The design, synthesis and biological evaluation of N-（2-（2-methoxyphenylthio） benzyl）-2-aryloxyethyl amines with dual 5-HT1A/SSR/activities are reported. Compound 8e displays the best dual activities and is a promising lead compound for further SAR studies.

作者 Xue Dan Wu Dong Zhi Liu Ai Jun Li Xue Qin Zhou

机构地区 School of Chemical Engineering and Technology College of Chemical and Pharmaceutical Engineering

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第3期295-298,共4页 中国化学快报（英文版）

关键词 Antidepressants 5-HT1A/5-HTT 5-HT1A receptor Diphenylsulfide Aryloxyethylamines Antidepressants 5-HT1A/5-HTT 5-HT1A receptor Diphenylsulfide Aryloxyethylamines

分类号 TQ46 [化学工程—制药化工]

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参考文献18

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Chinese Chemical Letters

2008年第3期

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N-(2-(2-Methoxyphenylthio)benzyl)-2-aryloxyethylamines:Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities 被引量：1

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