1997～2006年围产儿出生缺陷监测变化趋势分析

Anlyze the Change Tendency of Perinatal Babies Birth Defects from 1997 to 2006

目的调查青岛市城区出生缺陷发生的动态变化,了解相关因素。方法对1997.1-2006.12间24800例围产儿出生缺陷监测资料进行分析比较变化趋势。结果1997.1-2000.12,2001.1-2003.12,2004.1-2006.12出生缺陷发生率分别为7.72‰、6.05‰、10.76‰,三者比较呈上升趋势(P<0.05);先天性心脏病发生率分别为0.76‰、0.88‰、2.89‰,逐渐上升(P<0.01).总唇裂发生率分别为1.53‰、1.33‰、2.49‰,无明显改变(P>0.05);神经管缺陷发生率分别为0.85‰、0.6.‰、1.29‰,无明显改变(P>0.05)。出生缺陷与各相关因素中,母亲年龄35岁以上组出生缺陷发生率显著高于35岁以下各母龄组(P<0.05),无季节、性别等方面差异(P>0.05)。结论我市城区出生缺陷发生率呈上升趋势,应采取有效的行政和医疗保健干预措施,围婚期保健不能忽视。

Objective To understand change tendency and relative factor of perinatal babies birth defects. Methods The check-up data of 48000 cases of perinatal babies birth defects were analysed from January 1997 to December 2006. Results The total incidence of perinatal babies birth defects in January 1997 to December 2000, January 2001 to December 2003, January 2004 to December 2006 were 7.72‰, 6.05‰, 10.76‰ respective, which had significant difference （P〈0.05）. The incidence of Congenital heart defect （CHDs）were 0.76‰, 0.88‰, 2.89‰, respective; The incidence of Cleft lip with or without cleft palate, （CIJP）1.53‰, 1.33‰, 2.49‰; The incidence of Neural tube defects （NTDs）0.85‰,0.6.%,1.29‰. CHDs has more and more hight rate （P〈0.01）. The total incidence of perinatal babies birth defects which the mothers aged beyond 35 years was higher than that of the mothers aged before 35 yearn Conclusion The total incidence of perinatal babies birth defects of Qingdao ascends from 1997 to 2006. It is necessary to enhance effective intervention pregram in health care.Arround marriage period health care is more important.