造影剂对重症急性胰腺炎大鼠胰腺病理学的影响

Effects of contrast medium on the pancreatic pathology in severe acute pancreatifis experiment with rats

目的探讨造影剂对重症急性胰腺炎胰腺病理学的影响。方法选用健康Wister雄性大鼠，除空白对照组外，制备重症急性胰腺炎模型后，随机分为4组：重症急性胰腺炎组、重症急性胰腺炎注射生理盐水对照组、重症急性胰腺炎注射76％泛影葡胺组、重症急性胰腺炎注射优维显300组，每组6只。对胰腺损伤进行病理评分分析。结果SAP组（6．5±1．2）、SAP盐水对照（7．7±1．0）、SAP泛影葡胺组（7．5±1．5）、SAP优维显组（7．2±1．2）与空白对照组（3．2±1．7）相比较病理学评分明显增高，差异均有统计学意义（均P〈0．05）。但是这4组组间两两比较，则P〉0．05，差异无统计学意义。结论造影剂对重症急性胰腺炎胰腺病理改变没有产生负面作用，不会加重急性胰腺炎病情。

Objective To investigate the effects of contrast medium on the pancreatic pathology in severe acute pancreatitis （SAP）. Methods Twenty-four Wister rats underwent injection of sodium taurocholate into the biliopancreatic duct to establish models of SAP and then randomly divided into 4 groups： Group A （SAP group）, Group B （SAP models injected with normal saline injected group）, Group C （SAP models with injection of 76% cardiografin）, and Group D （SAP models injected with ultravist- 300）. Another 6 rats were used as blank controls. The rats were killed to undergo pathological examination of their pancreases. Modified Schmidt method was used to score the pathological changes. Results The modified Schmidt scores of Groups A, B, C, and D were （6.5 ± 1.2）, （7.7 ± 1.0）, （7.5 ± 1.5 ） , and （7.2 ± 1.2） respectively, all significantly higher than that of the control group [ （ 3.2 ± 1.7 ）, all P 〈 0.05 ]. However, there was no significant difference among these 4 groups （ all P 〉 0.05 ）. Conclusion CM has no adverse effects on the pathology of pancreas with SAP and does not worsen the disease.