腹膜功能的评估在尿毒症患者腹膜透析中的临床应用研究

Practical application of modified peritoneal equilibrium test in peritoneal dialysis patients

目的探讨改良腹膜平衡试验(改良PET)在尿毒症患者腹膜透析中的应用。方法腹膜透析患者在1个月内分别进行改良PET和标准PET测定,并根据改良PET结果调整透析方案,随访3个月观察患者透析充分性及营养状况的变化。结果所有患者均完成本研究,改良PET与标准PET显著相关(r=0.79,P<0.01),患者在研究开始与随访3个月时透析充分性指标(Kt/Vurea)及营养状况指标(ALB)分别为(1.45±0.30;1.84±0.38,P<0.05)与(29.12±3.59;38.15±4.22,P<0.01)。随访结束时患者的透析充分性及营养状况指标均有显著改善。结论改良PET与标准PET具有较好的相关性,并能指导透析方案的调整,从而有利于充分透析及营养状况的改善。

Objective：To investigate the role of modified peritoneal equilibrium test（modified PET） in peritoneal dialysis （PD） patients. Methods： Modified PET and standard PET were performed in PD patients in one month respectively. There PD schemes were adjusted according there results of modified PET, and patients were followed 3 months in order to observe the changes of dialysis adequacy（assessed by Kt/Vurea） and nutrition status（assessed by Alb）. Results： All patients completed this follow-up study. Modified PET was positively correhted with standard PET（r=-0.79 P〈0.01）. the parameters of dialysis adequacy and nutrition status in the beginning and at the end of this study are 1.45±0.30,1.84±0.38,（P〈0.05）and 29.12±3.59,38.15±4.22, （P〈0.01） respectively. Conclusion： This study demonstrated that modified PET is helpful to make a reasonable PD scheme, and can improve the dialysis adequacy and nutrition status.