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脑源性神经营养因子在涎腺腺样囊性癌中的表达及意义 被引量：1

Expression of Brain-derived Neurotrophic Factor in Salivary Adenoid Cystic Carcinoma and its Significance
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摘要 [目的]探讨脑源性神经营养因子(BDNF)与涎腺腺样囊性癌(SACC)的关系。[方法]采用免疫组织化学方法检测45例SACC切片中BDNF的表达,并统计分析BDNF与SACC组织学分型、临床分期、神经侵犯和远处转移之间的关系。[结果]BDNF在SACC中的阳性表达率为84.4%(38/45),BDNF表达强度与SACC的组织学分型和神经侵犯无明显关系(P>0.05),而与临床分期、远处转移关系密切(P<0.05)。[结论]SACC中存在BDNF异常表达,而且BDNF可能促进了SACC的发生发展。 [Purpose] To investigate the relationship between the expression of brain-derived neurotrophic factor（BDNF） and salivary adenoid cystic carcinoma （SACC）. [Methods] The expression of BDNF in 45 cases with SACC was detected by immunohistochemistrial method. The relationship between BDNF expression and histological type,clinical staging,perineural invasion and distant metastasis was analyzed. [Results] The positive expression of BDNF in SACC was 84.4%（38/45）. The expression level of BDNF wasn’t significantly correlated with histological type and perineural invasion （P〉0.05）,but correlated with clinical staging and distant metastasis （P〈0.05）. [Conclusions] BDNF is aberrantly expressed in SACC,and it might promote carcinogenesis and progression of SACC.
作者 张凯 黄全顺 李建成 徐涛 陈永锋 高廷益
机构地区 蚌埠医学院附属医院
出处 《中国肿瘤》 CAS 2008年第3期221-223,共3页 China Cancer
基金 安徽省自然科学基金(KJ2007B361zc)
关键词 涎腺肿瘤 癌 腺样囊性 脑源性神经营养因子 免疫组织化学 salivary gland neoplasms carcinoma,adenoid cystic brain-derived neurotrophic factor immunohistochemistry
分类号 R739.4 [医药卫生—肿瘤]
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参考文献9

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共引文献2

同被引文献15

  • 1苏立新,张陈平,胡永杰,周晓健,叶金海,李思毅.BDNF和TrkB在唾液腺腺样囊性癌中的表达及意义[J].中国口腔颌面外科杂志,2006,4(5):330-335. 被引量：6
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中国肿瘤
2008年 第3期

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