肝素应用于深Ⅱ度烧伤创面的临床观察

Clinical observation of the effect of heparin on deep partial thickness burn wound

目的:探讨肝素对深Ⅱ度烧伤创面的治疗效果。方法:伤后24h入院的烧伤患者30例,3%～50%烧伤面积,以深Ⅱ度为主,清创后实验区先用肝素钠湿敷,再用磺胺嘧啶银乳膏包扎,对照区应用磺胺嘧啶银乳膏包扎,每日1次,3天后改为半暴露。观察创面疼痛缓解、水肿消退、愈合时间等。结果:实验区创面肝素湿敷数分钟后疼痛明显减轻,水肿消退快,愈合时间明显少于对照区。结论:肝素直接外用于深Ⅱ度烧伤创面能缓解疼痛,缩短愈合时间。

Objective To investigate the effects of heparin on deep partial thickness burn wound. Methods Thirty cases inflicted with 3%-50% TBSA deep partial thickness burn wound, after fresh wound was debrided, the treating area was handled with heparin and Sulfadiazine silver cream, while the control area was treated with Sulfadiazine silver cream, until the wound healing. Reliving pain and the wound healing time were observed simultaneously. Results Pains were relieved after the wound handled with heparin; the wound healing time was much shorter in Heparin area than in SD-Ag area（P〈0.05）. Conclusion It is suggested that topical application of heparin to deep partial thickness burn wound may alleviate the progressive tissue damage, relive pain during early stage and promote wound healing.