不同解剖部位皮肤斑贴试验结果比较和分析

Comparison and analysis on patch test results of different site

目的:比较面部、前臂和背部三个部位同一产品局部封闭式斑贴试验结果的差异。方法:以2006年8月～2006年12月在北京空军总医院化妆品皮肤病专科门诊投诉化妆品过敏的患者为研究对象,判断标准采用《化妆品皮肤病诊断标准及处理原则总则》中的7项化妆品皮肤病诊断国家标准(GB17149.1～7-1997),统一登记表格记录化妆品皮肤病患者的病史资料及相关化妆品信息,分别在面部、前臂和背部进行同一产品的斑贴试验,对斑试结果进行统计学分析。结果:共112例患者完成了318个产品的斑贴试验,面部阳性反应例数最多,62例(占总患者的55.36%),84个产品(占总产品数的26.42%);其次为前臂,39例(34.82%),59个产品(18.55%);背部38例(33.93%),52个产品(16.35%)。面部和背部、面部和前臂斑试结果之间的差异有统计学意义,背部和前臂斑试结果之间的差异无统计学意义。结论:在进行化妆品的斑贴试验中,面部皮肤较前臂和背部敏感。

Objective To compare the different results of patch test which applied on face, forearm and back with the same product the patients had used. Methods The outpatients with cosmetic dermatosis were collected from Department of Dermatology, Air Force General Hospital between August and December in 2006, according to GB17149. 1～7 - 1997. The patients＇ case histories and the suspected cosmetics were recorded. The routine patch tests using the involved cosmetic products were carried out on each patient＇s face, forearm and back simultaneously. Results Totally, we performed patch tests on 112 patients with 318 products which they had used. The highest rate of positive reaction appeared on the face. There were 62 patients （55.36%） and 84 products （26.42%） showed positive reaction on face, 39 patients （34.82%） and 59 products （18.55%） on forearm, 38 patients （33.93%） and 52 products （16.35%） on back. Statistically, there was a significant difference between the results of patch tests applied on face and forearm, between face and back, but no difference between patch tests applied on back and forearm. Conclusion In cosmetic patch tests, the facial skin is more sensitive than that of forearm and back.