无水茶碱缓释片治疗慢性喘息性支气管炎的疗效及肺功能和血药浓度的变化

The effect of protheo on pulmonary function and the change of its plasma concentration in patients with chronic asthmatic bronchitis

目的为了解无水茶碱缓释片（ｐｒｏｔｈｅｏ）治疗慢性喘息性支气管炎的疗效。方法对３１例慢性喘息性支气管炎患者使用Ｐｒｏｔｈｅｏ每日一次４００ｍｇ口服，连续治疗６周。结果治疗后肺功能比治疗前明显好转，治疗时间越长，改善越明显，停药后２周仍明显高于用药前。医患双方对临床疗效评价的有效率分别为８７％、８１％。用药后４小时、２４小时，２周、４周、６周的茶碱血浓度均在有效浓度之间，呈一种稳态状态，不良反应轻微。结论使用ｐｒｏｔｈｅｏ治疗慢性喘息性支气管炎有良好的疗效，治疗持续时间越长，效果越好，并且血药浓度稳定、安全。

Objective In order to study the effect of protheo on pulmonary fuction and the change of its plasma concentration in patients with chronic asthmatic bronchitis. Method 31 patients with chronic asthmatic bronchitis were treated by taking protheo 400 mg once a day orally for 6 weeks. The pulmonary functions, including FEV 1, FVC, FEV 1/FVC and PEFR, and the plasma concentrations of theophylline were measured respectively before and after the administration. Results The results showed that the pulmonary functions after the therapy were greatly improved compared with that before the therapy, even after the administration for two weeks. In the second, fourth, sixth week of the therapy, the plasma levels of theophylline after taking protheo for 4 hours and 12 hours were both within the effective concentration. Conclusion Protheo is a kind of medicine with good effect, steady plasma concentration and less side effect for the patients with chronic asthmatic bronchitis.