羟基磷灰石负载锰催化溴苯的Suzuki反应

Suzuki Reactions of Aryl Bromides Catalyzed by Hydroxyapatite-Supported Manganese

以羟基磷灰石（HAP）负载Mn作为催化剂（MnHAP）催化溴苯与苯硼酸的Suzuki交叉偶联反应.以氟离子交换羟基磷灰石的羟基（MnFAP）后,催化剂的活性显著提高,在优化的反应条件下能得到约70%的产率.进一步考察了溶剂和不同取代基的影响.结果表明,MnFAP作用下溶剂极性对反应有很大影响,当溶剂DMF/H2O比例为1/3时产率最高.对于不同取代基取代的溴代芳烃或苯硼酸,可以得到中等产率（18%~46%）的偶联产物.

Suzuki cross-coupling reactions between aryl bromides and phenylboronic acids were studied over a hydroxyapatite-supported Mn catalyst （MnHAP） for the first time. An increased yield was obtained over the fluoride ion-exchanged hydroxyapatite-supported Mn catalyst （MnFAP）, Under optimized conditions, the yield was about 70 %. The effect of solvent compositions and different substituents were studied over the MnFAP catalyst. The DMF-H2O mixture with a DMF/H2O volume ratio of 1/3 was the best solvent. Moderate yields （18%- 46 % ） were obtained for all tested aryl bromides and phenylboronic acids substituted by different groups.