颞叶癫痫内侧颞叶结构体积变化及与临床因素相关性研究

Volume change of the mesial temporal structure and the relationship between the volume variety and clinical factors in temporal lobe epilepsy

目的:探讨颞叶癫痫(TLE)海马、杏仁核及内嗅皮层体积变化及与临床的相关性。方法:采用MRI对117例TLE患者的海马、杏仁核及内嗅皮层体积进行测量并进行临床相关性研究。结果:有侧别优势的TLE患侧海马体积较对侧小,其中海马硬化组患侧和对侧内嗅皮层体积也存在差异,而杏仁核体积均未见明显差异;海马及杏仁核体积变化与发作频率、起病年龄的早晚、病程长短、高热惊厥之间未见明显相关性,海马硬化组内嗅皮层体积减少程度与复杂部分性发作频率存在相关性。结论:内侧颞叶结构对颞叶癫痫相关的损伤敏感性存在差别。

Objective： To explore the volume change of hippocampus, amygdala and entorhinal and the relationship between the volume change of the mesial temporal structure and clinical factors in temporal lobe epilepsy （TLE）. Methods： To measure the volume of hippocampus, amygdala and entorhinal of 117 TLE patients with MRI and explore the relationship between the volume change and clinical factors. Results： The ipsilateml volume of hippocampus in unilateral TLE were significantly lower than the eontralateml side. In TLE with hippocampal sclerosis the volume of the ipsilateml entorhinal cortex were significantly lower than the eontralateml. The volume of amygdala were not significantly different. The degree of hippocampus, amygdala volume reduction was not related with the frequency of simple partial seizures, age of seizure onset, duration of seizure and history of febrile convulsions. The degree of entorhinal cortex reduction was related with the frequency of simple partial seizures. Conclusions： The vulnerability of mesial temporal structure were different.