盐酸米诺环素软膏治疗慢性牙周炎的疗效观察

Therapeutic effect of minocycline hydrochloride in treatment of chronic periodontitis

目的:评价盐酸米诺环素软膏治疗慢性牙周炎的临床疗效。方法:选择临床上诊断为慢性牙周炎的患者75人,共150颗患牙,按就诊顺序,分为试验组(75例牙用盐酸米诺环素软膏)和对照组(75例牙用20g/L碘甘油),试验前后检查牙龈指数和牙周袋深度,结合临床症状进行综合评价。结果:试验前两组基线资料具有均衡性。用药4周后,试验组牙龈指数和牙周袋深度明显好转,临床疗效综合评价,试验组优于对照组,差别有统计学意义(P<0.05)。结论:盐酸米诺环素软膏治疗慢性牙周炎疗效显著,具有一定的临床运用价值。

Objective：To evaluate the therapeutic effect of minocycline hydrochloride on chronic periodontitis. Methods ：150 teeth of 75 patients dagnosed as chronic periodontitis were divided as test group（75 teeth treated by minocycline hydrochloride） and control group（75 teeth treated by 20g/L iodoglycerin）.The effect of medicines were evaluated by clinical symptom combined with gingival index and the depth of pocket which were examined before and after treatment. Results：The baseline data of two groups indicated equilibrium.The status aroud the tested teeth in test group were improved,which was better than control group after 4-week treatment.The therapeutic effect of minocycline hydrochloride was better than iodoglycerin and there was statistic difference（P〈0.05）. Conclusion：Minocycline hydrochloride shows significant effect on chronic periodontitis.