静注异丙酚、咪唑安定对血流动力学及呼吸功能的影响

EFFECTS OF MIDAZOLAM AND PROPOFOL ON HEMODYNAMICS AND RESPIRATION IN HUMAN

比较静注异丙酚和咪啶安定对血液动力学及呼吸功能的影响。

Objective: The haemodynamic and respiratory changes folowing intravenous administration with propofol and midazolam have been compared. Methods: Sixty surgical patients (ASA Ⅰ ~ Ⅱ ) were subdivided into two groups according to an open, random sequence. (1 ) Propofol Group (n = 30 ); (2 )Midazolam Group (n = 30). After intravenous administration of equipotent doses of propofo and midazolam, the haemodynanic and respiratory effects have been observed. Results: Propofol caused a greater decrease in MAP, HR, SVRI than midazolam. No significant differences were found in CI. There were significant higher incidence and longer duration of apnea after propofol, and the increases in PaCO2 produced by propofol were also higher than those by midazolam. Conclusion: Midazolam may be less depressant to cardiorespiratory system than propofol.