2型糖尿病患者性别、肥胖对血中RBP4和TNF-α的影响

Effects of Gender and Obesity on Serum RBP4 and TNF-α in Type 2 Diabetes Mellitus

目的:检测不同性别2型糖尿病患者正常体重组和肥胖组的血清视黄醇结合蛋白4(RBP4)和肿瘤坏死因子α(TNF-α)水平,探讨两者与体脂,糖类、脂类代谢,胰岛素敏感性等的相关性.方法:采用HOMA-IR评价各组胰岛素敏感性,测定受试者的体重指数(BMI),腰臀比(WHR),检测空腹状态下血清RBP4、TNF-α、血糖、HbA1c、血脂和胰岛素水平.结果:超重或肥胖者,RBP4及TNF-α浓度均比体重正常者高;男性RBP4浓度均比女性高,TNF-α浓度无性别差异.RBP4与TNF-α显著正相关.Pearson相关分析:不论性别,血清RBP4和BMI、WHR、TG及HOMA-IR均有显著正相关(P<0.05).而TNF-均与腹内型肥胖、脂代谢有关。

Objective： To assay serum retinol binding protein-4 （RBP4） and TNF-α levels in patients with type 2 diabetes mellitus in different gender and weight, and to explore the correlation between the two factors and anthropometric parameter, glucose and lipid metabolism parameters and insulin sensitivity index etc. Methods： insulin sensitivity was assessed by HOMA-IR. Meanwhile the anthropometrical parameters such as body mass index （BMI） and waist hip ratio （WHR） were evaluated and the serum RBP4, TNF-α, glucose, HbAlc, lipids and insulin levels were also measured in fasting status. Results： Serum RBP4 and TNF-α levels were significantly increased in patients with obesity; Serum RBP4 level in male was significantly higher than that in female while TNF-α level had no difference in different gender. There was also a positive correlation between RBP4 and TNF-α. Pearson correlation analysis showed that serum RBP4 correlated positively with BMI, WHR, TG and HOMA-IR （P 〈 0.05）. TNF-α which had a negative correlation with HDL-C （P 〈 0.05）, correlated significantly with all index but HbAlc and LDL-C. Conclusion： Both of RBP4 and TNF-α correlate with WHR and lipid metabolism, TNF-α also has a correlation with glucose metabolism. There maybe synergistic effect of RBP4 and TNF-α in insulin resistance.