法莫替丁生物黏附缓释片的体外释放研究

In Vitro Release Characteristic of Famotidine Bioadhesive Sustained-Release Tablets

目的:评价法莫替丁生物黏附缓释片的体外释放特性。方法:建立法莫替丁生物黏附缓释片释放度的高效液相色谱测定法,运用Higuchi方程、Ritger-Peppas方程拟合其释放过程,采用Peppas修正式分析释放过程中不同机制的释药比例。结果:Ritger-Peppas方程更能拟合法莫替丁生物黏附缓释片的释放,凝胶骨架溶蚀机制在法莫替丁生物黏附缓释片的释放评价中占有更重要的地位。结论:Peas修正式可定量评价法莫替丁生物黏附缓释片的体外释放。

OBJECTIVE： To evaluate the release properties of the famotidine bioadhesive sustained - release tablets in vitro. METHODS： The HPLC method was used to determine the release of famotidine bioadhesive sustained- release tablets and the release process was fitted by Higuchi equation and Ritger- Peppas equation. The contribution percent of the diffusion and the erosion release mechanisms was analyzed by Peppas modification formula. RESULTS： The release of famotidine bioadhesive sustained-release tablets was better fitted by the Ritger- Peppas equation, and the gel- matrix erosion release played a more important role than diffusion release in drug release. CONCLUSION： The release of famotidine bioadhesive sustained - release tablets in vitro can be evaluated quantitatively by Peppas modification formula.