摘要乳腺癌耐药蛋白(breast cancer resistance protein,BCRP)是近年发现的与肿瘤多药耐药有关的新的药物排出泵。BCRP属于ABC转运蛋白超家族的成员,它仅有6个跨膜区和1ATP结合位点,故被称为不完整转运分子。推测BCRP通过组成同二聚体或异二聚体构成跨膜通道而发挥功能。过表达BCRP的肿瘤细胞株对米托蒽醌、阿霉素、柔红霉素、鬼臼乙叉甙、
2Almond BA,Hadba AR,Freeman ST,et al.Efficacy of mitoxantrone-loaded albumin microspheres for intratumoral chemotherapy of breast cancer[J].J Control Release,2003.91(1):147-155.
3Maeda H,Bharate GY,Daruwalla J.Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect[J].Eur J Pham Biopharm,2009,71(3):409-419.
4Vauthier C,Duberuet C,Chauvierre C,et al.Drug delivery to resistant tumors:the potential of poly(alkyl cyanoacrylate)nanoparticles[J].J Control Release,2003,93(2):151-160.
5Zhang XG,Miao J,Dai go,et al.Reversal activity of nanostructured lipid carriers loading cytotoxic drug in multidrug resistant cancer cells[J].Int J Pharm,2008,361(1):239-244.
6Koziara JM,Whisman TR,Tseng MT,et al.In vivo efficacy of novel paclitaxel nanoparticles in paclitaxel-resistant human colorectal tumors[J].J Control Release,2006,112(3):312-319.
7Kester M,Heakal Y,Fox T,et al.Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer cells[J].Nano Lett,2008,8(12):4116-4121.
8Singh S,Bhardwaj P,Singh V,et al.Synthesis of nanocrystalline calcium phosphate in microemulsion-effect of nature of surfactants[J].J Colloid Interf Sci,2008,319(1):322-329.
9Morcol T,Nagappan P,Nerenbaum L,et al.Calcium phosphate-PEG-insulin-rasein(CAPIC)particles as oral delivery systems for insulin[J].Int J Pharm,2004,277(1-2):91-97.