不同脑梗死亚型患者血清Fractalkine浓度的差异

Differences of Serum Fractalkine Levels in Patients with Different Subtypes of Cerebral Infarction

目的:探讨不同牛津郡社区卒中项目(OCSP)亚型急性脑梗死患者血清Fractalkine(FKN)浓度的变化。方法:45例急性脑梗死患者按OCSP分型分为完全前循环梗死(TACI)组、部分前循环梗死(PACI)组、后循环梗死(POCI)组和腔隙性梗死(LACI)组。采用酶联免疫吸附法检测发病1～3d、7d、14d和28d时血清FKN浓度,比较各组间的差异。分析FKN浓度与相应时间点美国国立卫生研究院卒中量表(NIHSS)评分和3个月时Barthel指数(BI)的相关性。结果:各种亚型急性脑梗死患者血清FKN浓度均升高,TACI组最为显著;在不同时间点,血清FKN浓度变化大致为TACI>PACI>LACI>POCI,与相应时间点NIHSS评分呈正相关,与3个月时BI呈负相关。结论:血清FKN浓度的变化可能提示急性脑梗死各OCSP亚型患者炎症损伤的差异,并影响神经功能缺损程度和患者3个月时的转归。

Objective： To investigate the changes of serum fractalkine （FKN） levels in patients with acute cerebral infarction in different Oxfordshire community stroke project （OCSP） subtypes. Methods： Forty-five patients with acute cerebral infarction were divided into total anterior circulation infarct （TACI）, partial anterior circulation infarct （PACI）, posterior circulation infarct （POCI） and lacunar infarct （LACI） groups according to the OCSP classification. Enzyme-linked immunoadsorhent assay （ELISA） was used to determine the serum FKN levels at day 1 to 3, 7, 14, and 28 after the onset of cerebral infarction, and the differences among all groups were compared. The correlations among the FKN levels, National Institutes of Health Stroke Scale （NIHSS） scores at the corresponding time points and the Barthel index （BI） at 3 months were analyzed. Results： The serum FKN levels increased in patients with all subtypes of acute cerebral infarction. The TACI group was most significant; the changes of serum FKN levels at different time points were approximately TACI 〉 PACI 〉 LACI 〉 POCI, and they were positively correlated with NIHSS scores at the corresponding time points, but they were negatively correlated with the BI at 3 months. Conclusions： The changes of serum FKN levels may suggest that the differences of inflammatory injury in patients with all subtypes of acute cerebral infarction in OCSP, and they may also influence the degree of neurological deficit and the functional outcome of patients at 3 months.