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小细胞肺癌组织中突变型P53与Bcl-2蛋白的表达及意义 被引量：1

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摘要 目的探讨小细胞肺癌组织中突变型P53与Bcl-2蛋白的表达及意义。方法用SP免疫组化法检测40例小细胞肺癌组织中突变型P53与Bcl-2蛋白的表达情况,并将结果进行相关分析。结果小细胞肺癌组织中突变型P53与Bcl-2蛋白的阳性表达率明显高于正常肺组织(P<0.05)。突变型P53表达与淋巴结转移和TNM分期有关(P<0.05),而Bcl-2表达与之无关(P>0.05)。突变型P53与Bcl-2蛋白的表达有相关性(P<0.05)。结论小细胞肺癌组织中突变型P53蛋白与预后有关,Bcl-2蛋白与预后无关。
作者 邹志坚 黄传生 黄小路
机构地区 南昌大学第四附属医院 江西省肿瘤医院
出处 《实验与检验医学》 CAS 2008年第1期45-46,共2页 Experimental and Laboratory Medicine
关键词 小细胞肺癌 突变型P53蛋白 BCL-2蛋白 预后
分类号 R734.2 [医药卫生—肿瘤] R446.8 [医药卫生—诊断学]
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共引文献15

同被引文献11

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实验与检验医学
2008年 第1期

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