Obestatin与GPR39受体的最新研究进展

New Studies and Researches on Obestatin and GPR39

肥胖抑制素(obestatin)是新近发现的一种与食欲刺激素有关的多肽(ghrelin-associated peptide,GAP),可以结合孤儿G蛋白GPR39受体,抑制摄食、胃肠功能和体重的增加,被认为是食欲刺激激素(ghrelin)的生物学拮抗剂或阴阳活性多肽.但最新研究认为,obestatin不能与GPR39受体特异性结合,也不能改变ghrelin所诱导的生物学效应.鉴于上述不同的研究报道,就其相关研究成果作一概述.

Obestatin was a newly found ghrelin-associated peptide（GAP）, which could be bound to the orphan G protein-coupled receptor GPR39. Obestatin suppressed food intake, inhibited gastrointestinal function, and decreased body-weight gain which was regarded as the biological equally matched material or Yin and Yang activated polypeptide. However, recent reports indicated that obestatin could not specifically bind to GRP39 receptor, and could not alter ghrelin-induced biological functions. According to the reports above, researches related to obestatin and GPR39 were reviewed in the article.