PLA-PEG/Fe_3O_4磁性复合微球的制备与性能研究

Preparation and Characterization of Magnetic PLA-PEG/Fe_3O_4 Composite Microspheres

以油酸钠改性的Fe3O4纳米粒子为磁性内核,聚乳酸-聚乙二醇(PLA-PEG)嵌段共聚物为载体材料,吐温-80(Tween-80)为表面活性剂,采用非溶剂引起相分离的方法,制备了PLA-PEG/Fe3O4磁性复合微球,系统考察了PLA-PEG质量浓度、Fe3O4与PLA-PEG的质量比及搅拌速度等因素对磁性复合微球性能的影响,确定了制备PLA-PEG/Fe3O4磁性复合微球的最佳条件,并利用透射电镜、红外光谱仪、热分析仪、振动样品磁强计和紫外分光光度计,对所得产物的形貌、粒径、化学组成、Fe3O4的质量分数及磁性能进行了表征.

Magnetic composite microspheres, consisting of a magnetite core and a PLA-PEG copolymer shell, were prepared by phase separation method with acetone as organic solvent and Tween-80 as surfactant. Effects of experimental parameters, such as the concentration of PLA-PEG solution, Fe3O4/ PLA-PEG ratio and stirring rate were studied, especially on the particle size and size distribution. The optimum preparation conditions were obtained subsequently. Finally, the morphology, size, component, magnetite content and magnetic property of the product were investigated respectively by transmission electron microscopy （TEM）, fourier transform infrared spectroscopy （FTIR）, thermo-gravimetric analysis （TGA）, vibrating sample magnetometer （VSM） and ultraviolet and visible spectrophotometer （UV）. The prepared PLA-PEG/Fe3O4 composite microspheres with magnetic properties and biodegradable properties would provide practical application in drug targeting and controlled drug release.