血清PTH-M测定诊断271例慢性肾衰致继发性甲状旁腺功能亢进

CLINICAL APPLICATION OF SERUM PTH M DETERMINATION IN DIAGNOSIS OF SECONDARY HYPERPARATHYROIDISM INDUCED BY CHRONIC RENAL FAILURE

目的：探讨血清甲状旁腺激素Ｍ（ＰＴＨＭ）含量测定对诊断慢性肾功能衰竭（ＣＲＦ）导致的继发性甲状旁腺功能亢进（ＳＨＰ）的临床价值和意义。方法：利用双抗放射免疫测定法对２７１例ＣＲＦ患者作血ＰＴＨＭ含量测定。结果：约８６％的患者血ＰＴＨＭ含量＞２７ｎｇ／ｄｌ的正常参考水平，其中约２５％的患者血ＰＴＨＭ含量＞２００ｎｇ／ｄｌ。血ＰＴＨＭ含量和患者的年龄或性别不存在相关性，但血ＰＴＨＭ含量和患者经历血液透析年限呈正相关（ｒ＝０６００）。结论：血ＰＴＨＭ测定对诊断ＳＨＰ有重要的临床价值，并对ＳＨＰ的监测有一定的参考价值。

Objective:To evaluate the determination of serum parathyroid hormone M(PTH M)in diagnosing secondary hyperparathyroidism(SHP)induced by chronic renal failure(CRF).Methods:Using double antibody radioimmunoassay(RIA) method to determine serum PTH M in 271 CRF patients.Results:Serum PTH M levels of about 86% patients were above the 27 ng/dl normal reference,and about 25% cases exceed 200 ng/dl;serum PTH M has no apparent relation to age or sex.Serum PTH M has positive relationship to the duration period of experienced hemodialysis.Conclusion:The determination of serum PTH M is significant for the diagnosis of SHP and it may also be used in monitoring the SHP treatments.