低强度激光的生物光子学研究

Biophotonics on Low Intensity Laser

相对于激光的作用，本文将生物系统分为表层信息元和里层信息元。研究表明，低强度激光的生物效应，是通过表层信息元超辐射态的物理放大，和相继的信号跨膜转导所形成的生物放大两次级联放大作用实现的。关于激光信号的跨膜转导，我们首次提出了低强度激光的生物信息模型和生物信息转换模型，并通过应用进行了验证。

Low intensity laser therapy has been used in a variety of clinical trials and remains a controversial issue due to its uncertain mechanism. In this paper, it will be shown that the biological effects of low intensity laser on a biological system are realized by the cascade amplifications of the physical amplification of the superradiation state of the information unit of the biological system and the subsequent biological amplification of the transmembrane signal transduction. For the biological amplification, the biological information model of low intensity laser (BIML) and the biological information transformation model of low intensity laser (BITML) will be put forward. According to BIML, the absorption of light alters the conformation of membrane chromophore mediates the concentration change of intracellular messengers as following: Hot color (red, orange or yellow) laser irradiation activates cAMP phosphodiesterase through G i protein or activates phosphoinositide phospholipase C (PLC) through G q protein or activates protein kinase correlated membrane bound receptor: cAMP↓; Cold color (green, blue or violet) laser irradiation activates adenylate cyclase through G s protein: cAMP↑. According to BITML, under nondamadge condition, the biological effects of a laser irradiation would transform into the biological effects of the laser irradiation of its opponent color if its dose is larger than the corresponding threshold value. We studied biophotonics on low intensity laser by use of identical model and time approach on generation of biological information, and put forward BIML andBITML, and verified them by their applications. For laser biological system interaction, the information units of a biological system were classified into the direct information units which interact with laser directly and the indirect information units which interact with laser through one information unit or many information units. It was shown that the cascade amplifications holds for the interaction of low intensity laser with a direct information unit, and BIML and BITML hold for light cell interaction. They were verified by their successful applications at the cellular level and the clinical level. The cascade amplifications, BIML and BITML are effective.