慢性乙型病毒性肝炎患者红细胞参数临床价值再评价

Revaluation of the Clinical Significance of the Red Blood Cell Parameter in Patients with Chronic Hepatitis B Infection

目的进一步探讨慢性乙型病毒性肝炎患者红细胞参数变化的临床意义。方法测定200例慢性乙型病毒性肝炎患者及100例健康者的红细胞参数(Hb、MCV、RDW-CV)及其肝功能(ALT、TBIL、PT、γ-GT等),所得结果进行统计学分析。结果随着肝功损害程度的加重,血红蛋白(Hb)逐渐降低,红细胞平均体积(MCV)和红细胞体积分布宽度(RDW-CV)逐渐升高,除轻度组的Hb、RDW-CV与对照组之间和重度组的RDW-CV与肝硬化组之间比较无统计学意义(P>0.05)外,其他各组的Hb、MCV、RDW-CV与对照组和各组之间两两比较均有统计学意义(P<0.05,P<0.01)。Hb与PT、γ-GT呈负相关,MCV、RDW-CV与PT、γ-GT呈正相关(P<0.05,P<0.01)。结论检测乙型肝炎患者红细胞参数有助于了解肝脏功能损害程度,对肝病的诊断、治疗和预后评估有重要意义。

Objective To investigate the clinical significance of red blood cell parameter in patients with chronic hepatitis B infection. Methods The red blood cell parameter （Hb, MCV, and RDW-CV） and liver functions （ALT, TBIL, PT, and γ-GTI） of 200 patients with chronic hepatitis B infection and 100 healthy control subjects were determined and analyzed. Results With the aggravations of liver functions, the level of Hb was found to be decreased while the levels of MCV and RDW-CV were increased. There was no significant difference in red blood parameter between the mild disease group and the control group （P〉 0.05）, and also between the severe disease group and the cirrhosis group （P 〉 0.05）. Significant difference was observed between the stage Ⅱ-Ⅵ groups and control group, and also among the five disease groups （stage I , and stage Ⅲ-Ⅵ groups）. Significant negative correlation between Hb and PT, γ-GT was observed （P〈0.05）. In contrast, a significant positive correlation was observed between MCV, RDW- CV and PT, γ-GT （P〈0.01）. Conclusion Red blood cell parameter may be used to evaluate the level of liver damage in patients with hepatitis B infection. The information may be used to facilitate diagnosis, treatment, and prognosis of hepatopathy.