广州市一起登革热家族聚集性暴发事件的调查与分析

A Case of Family Cluster Outbreak of Dengue Fever in Guangzhou,China

目的探讨登革热家庭聚集性发病的流行病学特点及传播效率,为今后进行有效的预防和控制登革热暴发提供参考。方法采用现场流行病学调查方法对广州市一起登革热家庭聚集性暴发事件进行调查和分析;采用ELISA、RT-PCR和病毒分离的方法对标本进行检测。结果2006年8月广州市荔湾区发生一起登革热家庭聚集性暴发事件,该家族15名家庭成员先后共有6人发病,罹患率40.0%,其中6例患者登革热抗体IgM或IgG阳性3例,病毒分离阳性3例,荧光PCR检测阳性者1例,基因序列测序和病毒分离结果最终确定为登革Ⅰ型病毒。结论根据临床表现、实验室检测结果以及流行病学调查,虽然该家族部分患者登革热抗体为阴性,但病例发病均在一个最长潜伏期内,因此可以确定该家族发生了登革热聚集性暴发,荔湾区龙津中路龙兴里最有可能是共同感染地,感染来源不明,感染时间为家庭聚会日可能性大。

Objective To examine the epidemic characteristics and occurrence of a case of family cluster outbreak of dengue fever, and to provide reference for the control of dengue fever outbreak in community. Methods A case of family cluster outbreak of dengue fever in Guangzhou was investigated and analyzed. Serum samples were analyzed by ELISA, RT-PCR, and virus isolation, Results A case of dengue fever outbreak in Liwan district （2006） was identified in Guangzhou. 6 out of 15 family members were infected. Serological analysis revealed that 3 family members were seropositive for IgM and IgG. Virus was isolated from 3 infected members. Only one sample was found to be positive by the RT-PCR detection method. Sequence analysis showed that the virus was type 1 dengue virus. Conclusion According to the clinical features, laboratory analysis, and the results of epidemiological studies, the outbreak occurred within a family living in the L-wan district. The source of infection was unknown. The infection was probably occurred during the family gathering.