结缔组织生长因子在胃癌组织中的表达及其与预后的关系

Expression of Connective Tissue Growth Factor is associated with shorter survival in Gastric Cancer

目的:检测结缔组织生长因子(CTGF)在胃癌组织中的表达并探讨CTGF表达在患者预后判断中的意义。方法:应用免疫组织化学染色方法检测108例胃癌组织中CTGF的表达情况,分析CTGF表达与患者临床病理特征、术后生存时间之间的关系。结果:CTGF高表达常见于发生淋巴结转移的病例(P=0.038),CTGF表达水平低的患者术后五年生存率(48.4%)显著高于表达水平高的患者(23.9%,双侧log-rank检验,P=0.003 5)。Cox回归分析证明患者TNM分期(P<0.001)、肿瘤分化(P=0.027)和CTGF表达水平(P=0.016)是胃癌的独立预后因子。结论:胃癌组织中CTGF高表达与发生淋巴结转移和患者预后不良显著相关。

Objective：To investigate the significance of connective tissue growth factor （CTGF） expression in gastric cancer （GC）. Methods：Immunohistochemistry method was used to detect the expression of CTGF in 108 cases of gastric carcinoma tissue samples. The correlation between the expression of CTGF and clinicopathologic parameters as well as survival of the patients with GC was analyzed. Results ： High CTGF expression was significantly associated with lymph nodes metastasis （P= 0. 038） and lower postoperative 5 year overall survival rates （23.9 %） compared with those showing low CTGF expression （48.4 ^ ,P= 0.003 5）. Using a Cox regression analysis for the 108 patients, TNM stage （P〈0. 001）, differentiation （P= 0. 027） and CTGF expression （P = 0. 016） were independent prognostic indicators. Conclusions：High CTGF expression is associated with the risk of lymph nodes metastasis and a poor survival time in GC. CTGF is a useful prognostic marker for GC.