人参果皂苷对急性心肌梗塞犬血流动力学的影响

Effects of ginseng fruit saponins on hemodynamics in acute myocardial infarction dogs

目的:研究人参果皂苷(GFS)对急性心肌梗塞犬血流动力学的影响。方法:30只犬结扎左冠状动脉前降支6h制备急性心肌梗塞模型,GFS按2.5、5.0和10.0mg.kg-1分为3个剂量组,静脉滴注给药;阳性对照药生脉注射液(PAI)组静脉滴注PAI4.0mL.kg-1;梗塞模型组静脉滴注生理盐水,记录给GFS后犬心功能及血流动力学各参数变化。结果:与模型组比较,GFS5.0和10.0mg.kg-1组犬的心率(HR)减慢(P<0.05或P<0.01),收缩压(SBP)、舒张压(DBP)、左心室收缩压(LVSP)、左室压上升最大速率(+dp/dtmax)、左室压下降最大速率(-dp/dtmax)及心输出量(CO)增加(P<0.05或P<0.01),左室舒张期末压(LVEDP)降低(P<0.05或P<0.01),与PAI组比较差异无显著性(P>0.05)。结论:GFS能改善心肌的收缩和舒张功能,缓解心肌梗塞后的泵衰竭,同时能降低心肌耗氧量,有利于增加心肌供血。

Objective To study the effects of ginseng fruit saponins （GFS） on hemodynamics in acute myocardial infarction dogs. Methods The acute myocardial infarction models were induced by ligation left anterior descending coronary for 6 h in 30 dogs. GFS was divided into three doses groups （2.5, 5.0 and 10.0 mg·kg^1） and administered with intravenous drip. Pulse-activating injection was taken as positive control medicine and administered with intravenous drip. Infarction model group, normal saline was administered with intravenous drip. After treated with GFS （in dosages of 2.5-10 mg·kg^-1 iv drip ） for 90 min, the changes of parameters of heart function and hemodynamics were recorded. Results Compared with model control group, the heart rate （HR） was slowed （P〈0. 05 or P〈0. 01）; systolic blood pressure （SBP）, diastolic blood pressure （DBP）, left ventricular systolic pressure （LVSP）, maximum left ventricular rise rate （＋ dp/dtmax） and maximum left ventricular fall rate （-dp/dtmax）and cardiac output （CO） were increased （P〈0.05 or P〈0.01） ; and left ventricular end-diastolic pressure （LVEDP） was decreased after treated with GFS （in dosages of 5.0 and 10.0 mg·kg^-1 iv drip） for 90 min. Its effect was the same with pulse-activating injection. Conclusion GFS can improve myocardial systolic and diastolic function, and relieve pump failure after myocardial infarction. GFS can also decrease the myocardial volume of oxygen consumption to profit increasing myocardial blood-supply.