武汉地区216例肥胖2型糖尿病患者瘦素受体基因Gln 223Arg多态性分析

The polymorphism analysis of leptin receptor gene variant of Gln 223 Arg in patients with obesity and type 2 diabetes mellitus of Han people in Wuhan district

采用PCR-RFLP方法测定692例汉族人的瘦素受体(LR)基因Gln 223Arg变异,2型糖尿病合并肥胖组患者与单纯糖尿病组患者比较以及肥胖组与正常组比较,基因型和等位基因分布频率差异均有统计学意义(P<0·01),推测LR基因Gln 223Arg变异与2型糖尿病合并肥胖有关。

The assay of genotypes of Gln223Arg variant （PCR-RFLP） in 692 subjects of Wuhan Han population with obesity and type 2 diabetes showed that the frequencies of AA and AG genotytpes and A allele were higher in T2DM plus obesity than in isolated T2DM （all P〈 0.01）. Gln 223Arg variant in leptin receptor gene may be associated with pathogenesis of obese type 2 diabetes mellitus.