72例慢性肝病并发肝源性糖尿病的临床分析

Clinical analysis of 72 cases of chronic liver disease complicated with hepatogenic diabetes

目的:探讨慢性肝病并发肝源性糖尿病的临床特点、治疗及预后的关系。方法:回顾性分析72例慢性肝病并发肝源性糖尿病的临床资料。结果:肝硬化并发肝源性糖尿病65例(90.4%),慢性重型肝炎并发肝源性糖尿病5例,肝癌并发肝源性糖尿病2例。Child-Pugh肝功能分级:B级63例,C级9例。死亡4例,余好转出院。结论:肝功异常可引起糖代谢的障碍,严重者导致糖尿病。肝源性糖尿病的轻重与肝损害程度呈正相关。

Objective ：To explore the clinical characteristics, diagnosis, treatment methods and prognosis of chronic liver disease complicated with hepatogenic diabetes.Methods：From July 2001 to September 2006,72 patients admitted in our hospital were diagnosed as hepatogenic diabetes.The clinical data of 72 patients were collected from their records and analyzed retrospectively. Results：The incidence of hepatogenic diabetes were 90.4% （65/72） in cirrhosis and 6.9%（5/72） in severe chronic hepatitis respectively. Liver cancer accounted for 2 cases of hepatogenic diabetes. Liver function of 63 cases was level B and the other was level C. Most of them were discharged except 4 dead cases. Conclusion：The abnormal liver function may disturb glucose metabolism and lead to diabetes. The severity of hepatogenic diabetes are positively related to degrees of liver function damage. A combination of diet, preemptive liver protection and antivirus drugs are fundamental therapy for the disease and complementary insulin treatment is recommended. The prognosis of hepatogenic diabetes is fairly good.