用水螅再生试验预测化学物致畸性的研究

Predication Teratogenicity of Chemicals Using Hydra Regeneration Assay.

通过亚硝酸钠、苯甲酸钠、氟化钠、青霉素钠，以及丙酮酸钠对水螅的毒性实验和对水螅再生体的生长抑制性实验，研究了水螅再生试验应用于预测化学物致畸性的可行性．实验结果表明，亚硝酸钠、苯甲酸钠、氟化钠除了对水螅和再生体产生毒性作用外，还具有一定的致畸性；而青霉素钠和丙酮酸钠未显示出致畸性．与哺乳动物的致畸性试验结果相吻合．

In this paper,the hydra polyps regeneration assay was used to screen and predict the teratogenicity of sodium benzoate, sodium pyruvate,sodium fluride,sodium penicillin,and sodium nitrite.The results showed that sodium nitrite, sodium fluride and sodium benzoate are teratogens,while sodium penicillin and sodium pyruvate are not teratogens.These experimental results accord with the results of mammalian teratogenicity assay.The test is valuble to screen and predict teratogenicity of chemicals.