摘要
Akt,又称蛋白激酶B(PKB)对骨骼肌的生长和代谢具有举足轻重的地位,与之相关的多种分子信号通路在骨骼肌质量变化过程中扮演十分重要的角色。综述与骨骼肌质量变化相关的两个主要信号通路:一方面是与肌肉萎缩相关的Akt1/FOXOs/MAFbx/MuRF1信号通路;另一方面为与肌肉肥大相关的PI3K/Akt/mTOR/S6K1信号通路,从两方面介绍Akt在骨骼肌质量变化中所处的核心地位。此外,结合以上信号通路的理论基础,进一步解释不同的运动训练方式所导致的肌肉质量变化的分子机制,为运动状态下骨骼肌质量变化的分子机制提供有效的理论依据,从而为治疗与骨骼肌萎缩相关联的疾病提供有效途径。
Akt, also known as protein kinase B, play an important role in skeletal muscle growth and metabolism. Many molecular signaling pathways associated with it also play a key role in the change of skeletal muscle mass. This paper reviews two main signaling pathways in order to introduce the key role of Akt in it, one is Aktl/FOXOs/MAFbx/MuRF1 signaling pathway which associated with muscle atrophy; the other is PI3K/Akt/mTOR/S6K1 signaling pathway which associated with muscle hypertrophy. Besides, the author also explain the molecular mechanisms in the change of skeletal muscle mass caused by different exercise, which provide an useful theory to cure disease associated with skeletal muscle atrophy.
出处
《体育科学》
CSSCI
北大核心
2008年第3期73-78,共6页
China Sport Science
基金
上海市浦江人才计划项目(2007D09)。
关键词
AKT
骨骼肌质量
肌肉萎缩
运动训练
Akt
skeletal muscle mass
muscle atrophy
exercise training
