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瘦素基因多态性与非酒精性脂肪性肝病及胰岛素抵抗的相关性 被引量：3

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摘要 非酒精性脂肪性肝病（NAFLD）的发病与胰岛素抵抗相关。瘦素是一种能量平衡的调节激素，其主要作用是控制食物摄人和调节能量代谢。瘦素水平与肝脂肪变的严重程度和肝纤维化相关，本研究通过检测广州市城区居民NAFLD和正常人瘦素启动子区2548位的基因型和血浆中瘦素水平，探讨其与胰岛素抵抗及NAFLD的相关性。
作者 赖晓波 聂玉强 李瑜元 石胜利 杜艳蕾 周永建
机构地区 广州市第一人民医院消化科
出处 《中华消化杂志》 CAS CSCD 北大核心 2008年第2期126-127,共2页 Chinese Journal of Digestion
关键词 非酒精性脂肪性肝病 胰岛素抵抗 瘦素水平 基因多态性 NAFLD 调节激素 能量平衡 能量代谢
分类号 R686 [医药卫生—骨科学]
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参考文献9

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二级参考文献15

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共引文献1379

同被引文献59

  • 1范建高,朱军,李新建,李锐,戴菲,宋晓敏,陈兰,李锋,陈世耀.上海市成人脂肪肝患病率及其危险因素流行病学调查[J].中华肝脏病杂志,2005,13(2):83-88. 被引量：582
  • 2周永健,李瑜元,聂玉强,黄健,石胜利,李永强,杜艳蕾.肿瘤坏死因子-α基因多态性与非酒精性脂肪性肝病的关系[J].中华消化杂志,2006,26(5):311-314. 被引量：14
  • 3樊锦秀,金国健,朱慧民,王爱华,张黎明,陈琪.老年人非酒精性脂肪肝与载脂蛋白E基因多态性关系的研究[J].中华老年医学杂志,2006,25(6):428-430. 被引量：7
  • 4刘珉,刘伟,郑升,张宏利,骆天红,罗敏.乙酰辅酶A羧化酶β基因多态性与2型糖尿病易感性关系的初步研究[J].中国糖尿病杂志,2006,14(4):255-257. 被引量：6
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引证文献3

二级引证文献9

中华消化杂志
2008年 第2期

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