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钙结合蛋白S100A1与心力衰竭 被引量：1

S100A1 protein and heart failure
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摘要 钙结合蛋白S100A1被认为是一种钙依赖性心脏收缩因子。心力衰竭时S100A1蛋白表达减低,增加S100A1蛋白表达可通过调节心肌钙转运、抑制心室重构、减少心肌细胞凋亡和恢复心肌能量供应等机制增加心脏收缩功能,因此恢复衰竭心肌内S100A1蛋白水平是治疗心力衰竭的有效措施。 S100A,a Ca^ 2＋-depending inotropic factor in the heart,is found decreased during hear failure. Increase of S100A1 protein expression can improve cardiac function by regulating Ca^2＋ transportation,inhibiting left ventricular remodeling, decreasing apoptosis, and restoring energy supply of failing heart. Therefore, recovery of S100A1 protein expression in the failing heart is an effective strategy for treatment of heart failure.
作者 许如意 高连如 杨晔
机构地区 第二军医大学研究生院 海军总医院心内科
出处 《第二军医大学学报》 CAS CSCD 北大核心 2008年第3期331-333,共3页 Academic Journal of Second Military Medical University
关键词 S100A1蛋白 心肌收缩 心力衰竭 钙 S100A1 protein myocardial contraction heart failure calcium
分类号 R541.6 [医药卫生—心血管疾病]
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参考文献17

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第二军医大学学报
2008年 第3期

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