摘要
目的:观察复方沙棘籽油栓对大鼠阴道及宫颈糜烂动物模型的治疗作用。方法:通过阴道内注入苯酚胶浆和阴道内黏膜下注射金黄色葡萄球菌造成大鼠阴道及宫颈糜烂动物模型。结果:苯酚胶浆致大鼠阴道和宫颈糜烂动物模型,复方沙棘籽油栓各剂量组和模型组比较,阴道和宫颈重量指数降低,黏膜及黏膜下病理损伤明显减轻,与模型组比较有显著差异(P<0.05,P<0.01);金黄色葡萄球菌致大鼠阴道和宫颈糜烂动物模型,复方沙棘籽油栓各剂量组白细胞总数、阴道和宫颈重量指数降低,黏膜及黏膜下病理损伤减轻(P<0.05,P<0.01)。结论:复方沙棘籽油栓对化学灼伤和生物因子感染致大鼠阴道及宫颈糜烂模型有一定的治疗作用。
Objective:To observe the effect of compound Shajizi suppository on model rats with vaginal and cervical ero- sion.Methods:Experiment 1:48 rats were randomly divided into blank group, model group, Gongjing Yankang suppository group,compound Shajizi suppository treatment group 1 (high dosage),group 2(middle dosage) and group 3 (low dosage). The vaginal and cervical erosion model rats were induced by intravaginal injection of phenol mucilage.Experiment 2:48 rats were divided into 6 groups as the same way mentioned above.The vaginal and cervical erosion model rats were induced by submucosal injection of staphylococcus.Results:Experiment 1 :compared with the model group,vaginal and cervical mass indexes were decreased,the pathological lesions of mucosa and submucosa were significantly improved in compound Shajizi suppository treatment groups.Experiment 2:compared with the model group,vaglnal and cervical mass indexes and the number of white blood cell were decreased,the pathological lesions of mucosa and submucosa were significantly alleviated in compound Shajizi suppository treatment groups.Conclusion:Compound Shajizi suppository has therapeutic effect on vaginal and cervical erosion model rats which were induced by chemical bum and biotic factors.
出处
《山西中医学院学报》
2008年第1期16-18,共3页
Journal of Shanxi College of Traditional Chinese Medicine
关键词
阴道及宫颈糜烂
复方沙棘籽油栓
病理改变
vaginal and cervical erosion, compound Shajizi suppository, pathological changes