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季膦盐4-羧丁基三苯基溴化膦的合成 被引量：1

Synthesis of ylide(4-carboxybutyl)triphenylphosphonium bromide
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摘要 4-羧丁基三苯基溴化膦广泛用于立体选择性药物的合成.以三苯基膦和5-溴戊酸为原料在乙腈溶剂中合成了季膦盐4-羧丁基三苯基溴化膦(C23H24O2BrP),产品用红外光谱和核磁共振等分析方法验证,确认合成了4-羧丁基三苯基溴化膦,为进一步的Wittig反应奠定了基础. The ylide （4-carboxybutyl）triphenylphosphonium bromide, which was widely used in the synthesis of stereo selectivity drug, was synthesized from triphenylphosphine and 5-bromovaleric acid in the solution of acetonitrile. The structure of the product was confirmed by IR and ^1HNMR.
作者 吴登瑜 李方实
机构地区 南京工业大学理学院
出处 《南京工业大学学报（自然科学版）》 CAS 2008年第2期87-89,共3页 Journal of Nanjing Tech University(Natural Science Edition)
关键词 4-羧丁基三苯基溴化膦 三苯基膦 合成 （4-carboxybutyl） triphenylphosphonium bromide triphenylphosphonium synthesis
分类号 R914.5 [医药卫生—药物化学]
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参考文献13

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  • 1Kaneyoshi Kato,Shigenori Ohkawa,Shinji Terao. Thromboxane synthetase inhibitors (TXSI).Design,synthesis,and evaluation of a novel series of omega-pyridilalkenoic acids[J].Medicinal Chemistry,1985,(03):287-294.
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  • 5Tzvetelina Ventzislavova Marquardt. A new synthetic pathway to epothilone analogues and an efficient approach to cyclohexenylamines as precursors for the total synthesis of epibatidine[D].Germany:The Eberhard-Karls-Universit(a)t Tübingen,2002.
  • 6Robert W,Richard W,John G. Pyridine compounds which are useful in treating a disease state characterized by an excess of platelet activating factors[P].US:4927838,1990.
  • 7Zhao Guolei,Yang Chao,Li Bing. A new phenylethyl alkyl amide from the ambrostoma quadriimpressum motschulsky[J].Journal of Organic Chemistry,2011.1342-1346.
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南京工业大学学报（自然科学版）
2008年 第2期

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