马来酸曲美布汀联合谷维素治疗肠易激综合征

Trimebutine maleate combined with bifid in the treatment of irritable bowel syndrome

目的探讨马来酸曲美布汀联合谷维素治疗肠易激综合征(IBS)的疗效。方法将61例IBS患者随机分为两组,治疗组31例用马来酸曲美布汀200 mg、谷维素60 mg,口服,3次/日;对照组30例使用氟西汀20 mg、谷维素20 mg,口服,3次/日;两组均以30 d为1个疗程。结果治疗组和对照组的显效率和总有效率分别是64.5%、90.3%和26.7%、53.3%,两组比较有显著性差异(P<0.01)。结论马来酸曲美布汀联合谷维素治疗IBS疗效明显。

Objective：To evaluate trimebutine maleate combined with bifid in the treatment of irritable bowel syndrome （IBS）. Methods： Sixtyone patients with IBS were randomly divided into two groups. The 31 patients of the treatment group were given each 200mg of trimebutine maleate and 60mg of bixqd, po,tid. The 30 patients of the control group were given 20mg of fluoxetine and 20mg of bifid, po,tid. Tile course of treatment in bothof the groups lasted for 30 days. Results： The curative effect and total effect in the treatment group were 64.5% and 90.3% while those of the control group were 26.7 % and 3.3 % （ P 〈 0.01 ）. The two groups had significant differences. Conclusion ： Trimebutlne maleate in combination with bifid is effective in the treatment of IBS.