摘要
目的探讨PTEN蛋白及P53蛋白与胆囊癌发生、发展的关系以及两者表达的相关性。方法采用免疫组织化学方法检测40例胆囊癌及10例正常胆囊组织中PTEN蛋白及P53蛋白的表达。结果胆囊癌组织中PTEN蛋白阳性表达率为30.0%(12/40),明显低于正常胆囊组织表达率90.0%(9/10),P<0.05。突变型P53蛋白的阳性表达率在胆囊癌中为47.5%(19/40),而正常组织未检测出。分析显示:PTEN表达与胆囊癌的转移情况有关,PTEN与P53蛋白在胆囊癌中表达呈高度负相关。结论PTEN缺失及P53突变蛋白参与了胆囊癌的发生,PTEN的低表达与胆囊癌的转移情况有关。
Objective To study the relationship between the expression of PTEN and P53 proteins and the development and malignancy of gallbladder carcinoma. Methods The expression of PTEN and P53 proteins in 40 cases of gallbladder carcinoma and 10 cases of normal gallbladder was detected by immunohistochemistry. Results The positive expression rate of PTEN protein in gallbladder carcinoma group was 30. 0% ,which was significantly lower than that in the control group 90. 0% （P〈0.05）. The positive expression rate of mutant P53 protein was 47. 5% in gallbladder carcinoma group, but it was not detectable in any of control group. Further analysis showed that the expression level of PTEN protein was correlated with the metastasis of carcinoma and had a negative-relation with P53 protein. Conclusion PTEN inactivation and P53 mutation may play important roles in the formation of gallbladder carcinoma. The low expression of PTEN protein was related with the metastasis.
出处
《华中医学杂志》
2007年第6期499-500,共2页
Central China Medical Journal
