系统性红斑狼疮患者激素治疗前后血清骨钙素、TNF-α、IL-8及C3测定

Changes of asteocalcin bone glaprotein propeptide,cell factor and C3 of SLE patients before and after treatment

目的:探讨系统性红斑狼疮(SLE)患者治疗前后骨钙素(BGP)、细胞因子(TNF-α、IL-8)的水平变化及对免疫功能的影响。方法:采用放免法及酶免法检测40例SLE患者激素治疗前后血清BGP、TNF-α及IL-8含量,采用速率散射比浊法测定补体C3含量。以30例正常体检者作对照。结果:治疗前40例SLE患者BGP水平低于正常对照组,而TNF-α及IL-8水平高于正常对照组(P<0.01),补体C3水平低下。激素治疗后,SLE患者血清BGP、TNF-α、IL-8水平均下降,C3水平升高(P<0.05)。结论:SLE患者经激素治疗后有骨丢失现象,TNF-α、IL-8及补体C3参与SLE疾病过程。

Aim： To investigate the changes of serum levels of bone glaprotein propep tide （BGP） ,TNF-α IL-8 and C3 of lupus erythematosus（SLE） patients before and after hormone treatment. Methods：A total of 40 SLE patients and 30 normal control people were subjected to detect the serum BGP,TNT-α IL-8 by RIA and ELISA, and C3 by immune rate nephelometry. Results：Compared with those of the control, BGP, C3 level of SLE patients were lower, however, TNF-α and IL-8 level were higher. Conclusion：Bone loss exists in SLE patients treated with hormone. TNF-α, C3 and IL-8 are related with the development and activity of SLE.