抗抑郁剂治疗手术后胃瘫综合征31例临床分析

Clinical analysis of postsurgical gastroparesis syndrome treated with antidepressant:a report of 31 cases

目的:探讨精神、心理因素与手术后胃瘫综合征的关系及抗抑郁剂对其的疗效。方法:对31例正常人和31例手术后胃瘫综合征患者进行汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)和症状自评量表(SCL-90)评分;31例手术后胃瘫综合征患者用5-羟色胺再摄取抑制剂(SSRI)西酞普兰治疗,疗程均为8周,治疗后再行量表评分。结果:3种量表(HAMD、HAMA、SCL-90)评分结果,均显示手术后胃瘫综合征患者的精神、躯体症状与正常人之间差异有非常显著性(P<0.01);手术后胃瘫综合征患者接受抗抑郁剂治疗8周后,精神和躯体症状均有明显改善。结论:手术后胃瘫综合征与精神心理因素相关,患者普遍存在抑郁和焦虑情绪,用抗抑郁剂治疗能显著改善精神和躯体两方面症状。

Objective：To investigate the role of psychological factors in postsurgical gastroparesis syndrome,and the effect of antidepressant treatment.Methods：Thirty-one patients with postsurgical gastroparesis syndrome were treated with antidepressants（citalopram）for 8 weeks.Before and after 8-week treatment,the psychological status of the patients were analyzed by Hamilton Depression（HAMD）,Hamilton Anxiety（HAMA）and SCL-90 scales,and compared to those of 31 health volunteers.Results：There were significant difference in somatic and psychological scores in HAMD,HAMA and SCL-90 scores between the two groups（P〈0.01）.The scores of pa- tients were significantly improved after 8 weeks of treatment（P〈0.01）.Conclusion：Psychological factors play a role in postsurgical gastroparesis syndrome.Antidepressants are effective in the treatment of disorder of psycho logical as well as physical function.