期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

干细胞联合血管内皮生长因子治疗缺血性脑损伤 被引量：1

Combined Treatment of Stem Cells and Vascular Endothelial Growth Factor in Ischemic Brain Injury
原文传递
导出
摘要 最近的动物实验研究表明，神经发生和血管生成是卒中恢复的重要机制。干细胞移植能改善卒中后神经功能缺损，而血管内皮生长因子也可通过促进血管生成改善卒中后神经功能。文章综述了二者联合应用治疗缺血性脑损伤的研究进展。 Recent animal experiments demonstrated that neurogenesis and angiogenesis involved in mechanisms of stroke recovery. Transplanted stem cells can improve the neurological function after stroke. Vascular endothelial growth factor can also improve the neurological function after stroke via enhenceing angiogenesis, This article reviews the advances in combined treatment of stem cells and vascular endothelial growth factor in ischemic brain injury.
作者 李俊雅 黎奔 郭建文 段晓红
机构地区 广州中医药大学第二临床医学院
出处 《国际脑血管病杂志》 2008年第2期137-140,共4页 International Journal of Cerebrovascular Diseases
基金 广东省自然科学基金（No.06301402）
关键词 缺血性卒中 干细胞 血管内皮生长因子 ischemic stroke stem cell vascular endothelial growth factor
分类号 R743.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献23

  • 1European Stroke Initiative Executive Committee and Writing Committee. The European Stroke Initiative recommendations for stroke management:update 2003. Cerebrovasc Dis, 2003, 16:311 -318.
  • 2Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian cereal nervous system. Science, 1992, 255: 1707 - 1710.
  • 3Ishibashi S, Saknguchi M, Kuroiwa T, et al. Human neural stem/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolia gerbils. J Neurosci Res, 2004, 78:215 -223.
  • 4Chu K, Kim M, Park KI, et al. Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia. Brain Res, 2004, 1016:145 - 153.
  • 5Lee HJ, Kim KS, Kim EJ, et al. Brain transplantation of immortalized human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model. Stem Cells, 2007, 25:1204 - 1212.
  • 6Friedenstein AJ, Petrakova KV, Kurolesova AI, et al. Heterotopic of bone marrow.Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation, 1968, 6:230-247.
  • 7Chen J, Zhang ZG, Li Y, et al. Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res, 2003, 92 : 692-629.
  • 8Borlongan CV, Lind JG, Dillon-Carter O, et al. Bone marrow gaffs restore cerebral blood flow and blood brain barrier in stroke rats. Brain Res, 2004, 1010:108-116.
  • 9Li Y, Chen J, Zhang CL, et al. Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells. Glia, 2005, 49:407 -417.
  • 10Bang OY, Lee JS, Lee PH, et al. Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol, 2005, 57:874 -882.

二级参考文献16

  • 1田士强,王任直,李桂林,王欣,张波,姚勇,窦万臣,孔燕国.大鼠局灶性脑缺血模型的改进[J].基础医学与临床,2004,24(4):449-451. 被引量：18
  • 2Fang B,Liao L,Shi M,et al.Multipotency of Flk1^+ CD34^-progenitors derived from human fetal bone marrow.J Lab Clin Med,2004,143:230-240.
  • 3Fang B,Shi M,Liao L,et al.Multiorgan engraftment and multilineage differentiation by human fetal bone marrow Flkl +/CD31 -/CD34-Progenitors.J Hematother Stem Cell Res,2003,12:603-613.
  • 4Li Y,Chen J,Wang L,et al.Treatment of stroke in rat with intracarotid administration of marrow stromal cells.Neurology,2001,56:1666-1672.
  • 5Zhao LR,Duan W,Reyes M,et aL Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the iscbemic brain of rats.Exp.Neurol,2002,174:11-20.
  • 6Honma T,Honmou O,Iiboshi S,et al.Intravenous infusion of immortalized human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat.Experimental Neurology,2005,20 (Available online).
  • 7Jiang Yuehua,Jabagirdar B N,Reinhardt R lee,et al.Pluripotency of mesenchymal stem cells derived from adult marrow.NATUBE,2002,418:41-49.
  • 8Jang-Bo Lee,Satoshi Kuroda,Hideo Shichinohe,et al.A preclinical assessment model of rat autogeneic hone marrow stromal cell transplantation into the central nervous system Brain Research Protocols,2004,14:37-44.
  • 9Chopp M,Li Y.Treatment of neural injury with marrow stromal cells.Lancet Neurol,2002,1:92-100.
  • 10Qin Chen,Yan Long,Yuan Xiaoqing.Protective Effects of Bone Marrow Stromal Cell Transplantation in Injured Rodent Brain:Synthesis of Neurotrophic Factors.J Neuroscience Research,2005,80:611-619.

共引文献11

同被引文献16

  • 1杨利,黄燕,蔡业峰.从“脑中血海”探讨出血中风、缺血中风的病机差异[J].江西中医药,2004,35(7):13-14. 被引量：6
  • 2黄培新,黄燕,卢明,杜宝新,梁伟雄,欧爱华,蔡业峰,郭建文,奚肇庆,陈眉,董少龙,陆晖,李军,东贵荣,李海聪,赵建军,刘茂才.急性脑出血中西医结合综合治疗方案研究[J].中国中西医结合杂志,2006,26(7):590-593. 被引量：50
  • 3卫生部疾病预防控制局.卫生部介绍第三次全国死因调查主要情况[R].[2008-04-29].http://cn.chinagate.cn/webcast/2008-04/29/content_15034864.htm.
  • 4http://www, eso-stroke, org/pdf/ES008 _ Guidelines _ English. pdf.
  • 5李经纬.寿养丛书全集[M].北京:人民卫生出版社,1993.178.
  • 6Y. Huang, J. Pei, X. Wang, Outcome and safety assessment of Yin pattern of acute ischemic stroke treated with an herbal medicine protocol[ J]. Cerebrovasc Dis,2007,24:483-494.
  • 7Urtado O, Pradillo JM, Alonso-Escolano D, et al. Neurorepair versus neuroprotection in stroke[ J]. Cerebrovasc Dis, 2006, 21 (Suppl 2) : 54-63.
  • 8Ohab JJ, Fleming S, Blesch A, et al. A neurovascular niche for neurogenesis after stroke [ J ]. J Neurosci, 2006, 26: 13007- 13016.
  • 9Thored P, Wood J, Arvidsson A, et al. Long-term neuroblast migration along blood vessels in an area with transient angingenesis and increased vascularization after stroke [ J ]. Stroke,2007, 38 : 3032-3039.
  • 10任继学.任继学经验集[M].北京：人民卫生出版社,2000.70.

引证文献1

二级引证文献2

国际脑血管病杂志
2008年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部