丁公藤的研究进展

Advances in Studies on Caulis Erycibes

综述丁公藤(Erycibe obtusif olia Benth.)在植物学、化学成分、药材标准和炮制、药动学、药理毒理以及临床应用等方面的研究进展,发现目前丁公藤化学成分的研究多集中在东莨菪内酯、东莨菪苷这两个成分的含量测定和丁公藤制剂的药理、毒理研究上,对丁公藤抗风湿、抗炎、镇痛等作用机制研究不够深入,丁公藤抗风湿、抗炎、镇痛等活性成分也还不是很清晰,建议将大果飞蛾藤(异萼飞蛾藤)(P.sinensisHemsl)和近无毛飞蛾藤(P.sinensisHemsl.var.delavayi Rehd.)作为丁公藤代用品进行研究,以扩大丁公藤的资源范围,并加强对丁公藤抗风湿、抗炎、镇痛等作用机制的研究,长期使用丁公藤注射液须注意其蓄积性。

By discussing the advance in studies on Caulis Erycibes in the field of botany,chemical composition,standards and processing,pharmacology and toxicological,clinical application.The research suggests that the focus of studies on Caulis Erycibes is on two aspects： the content measurement of Total Scopoletin and Scopolin and pharmacology and toxicological of Caulis Erycibes,but the mechanism of anti-rheumatism,anti-inflammation and antalgic is inadequately studied.It is recommended that research should be conducted on Porana.sinensis Hemsl and Porana sinensis Hemsl var delavayi Rehd as the substitutinon for Caulis Erycibes to enlarge the resource scope of Caulis Erycibes and strengthen research on anti-rheumatism,anti-inflammation and antalgic in Caulis Erycibes.It＇s necessary to pay attention to the accumulative toxicity of Caulis Erycibes when in long-term use.