摘要
以杂多酸H8SiW12O42为催化剂,以乙酰乙酸乙酯和间苯二酚为原料,通过Pechmann反应合成7-羟基-4-甲基香豆素。探讨了以H8SiW12O42为催化剂时反应温度、催化剂用量、原料比诸因素对产品收率的影响。实验表明,H8SiW12O42是合成7-羟基-4-甲基香豆素的良好催化剂,在反应温度为130℃,n(间苯二酚)∶n(三乙)=1∶1,催化剂的用量为0.6 g(间苯二酚的物质的量为0.04 mol)时,产品的收率为68.0%。
The synthesis of 7-hydroxy-4-methyl coumarin catalyzed by different heteropolyadd H8SiW12O42 from ethylaeetoaeetate and resorseinol under solventless condition was studied. The optimum conditions of H4SiW12O40 were as followed： molar ratio of ethylaeetoaeetate to resorseinol was 1 ： 1 ; the quantity of catalyst was equal 0.6 g（when resorseinol was 0.04 mol）, the reaction temperature was 130 ℃, the yield of 7-hydroxy-4-methyl coumarin could reach 68.0 %.
出处
《化工技术与开发》
CAS
2008年第3期14-16,共3页
Technology & Development of Chemical Industry
关键词
杂多酸
香豆素
无溶剂合成
heteropolyaeid
coumarin
solventless synthesis
