米非司酮配伍米索前列醇终止妊娠临床研究

A study on application of combined mifepristone and misoprostol for medical terminating in 10-16 week gestation

目的探讨米非司酮配伍米索前列醇终止10周～16周妊娠的效果及副反应。方法选择2276例妊娠10周￣16周要求终止妊娠的妇女,予米非司酮100mg口服,连服2d,第3天口服米索前列醇600μg。结果完全流产率90.04%,不全流产率8.70%,流产失败率1.27%;阴道流血量(58.2±18.3)ml;阴道流血时间(8.1±3.2)d;10d内止血率为86.48%;药物不良反应包括异常出血和轻度过敏反应(发生率8.9%);未发生严重并发症。结论米非司酮配伍米索前列醇用于终止10周￣16周妊娠安全有效,并发症少,可替代钳刮术,从而避免了宫颈损伤、胎儿骨片残留以及羊水栓塞等严重并发症的发生。

Objective To investigate the effect of combined mffepristone and misoprostol for medical terminating in 10-16 week gestation.Methods The outcome of 2276 cases of medical abortion in 10-16 week gestation by combined mifepristone and misopmstol was analyzed retrospectively. Women took mifepristone 100mg q.d, total among of 200mg, then plus misoprostol 600 μg at 8：00 in the morning on the 3th day,Results The rates of complete abortion, incomplete abortion and failed induced abortion were 90,04%, 8.70% and 1.27% respectively. Bleed loss was 58.2 ± 18.3ml and bleeding duration was 8.1 ± 3,2 days. While the rate of side effect including abnormal bleeding and mild allergic reaction was 8,9%. No severe complications was observed.Conclusion Combined mifepristone and misoprostol on medical termination in 10-16 week gestation is a safe and effective method with little pain and few complications. As a result, it could be substituted for forcep curettage on induced abortion in 10-16 week gestation to avoid operative complications including uterine perforation, fetal bones retained and amniotic fluid