新生儿心肌酶升高与缺氧关系的探讨

The study on the dependablity of myocardium enzyme and hypoxia in neonatus

目的分析新生儿窒息患者的血清心肌酶活性变化,观察酶活性的变化与缺氧程度的关系,探讨新生儿心肌酶升高与缺氧的关系,为临床新生儿缺氧评估提供一定的实验室诊断指标。方法回顾性分析我院2004年1月至2007年5月间115例新生儿窒息患者的血清心肌酶活性变化,比较缺氧与无缺氧新生儿心肌酶水平的变化情况。结果两组患者在AST、CK、CK-MB、LDH、HBDH和cTnI方面,存在明显差异,观察组血清心肌酶谱水平明显高于对照组(P<0·01),二者比较差异有统计学意义;把各心肌酶指标作为研究因素的混杂因素考虑,对各潜在影响因素与缺氧的关系作多元回归分析,发现AST、CK、CK-MB、LDH、HBDH和cTnI与新生儿缺氧明显正相关(P<0·01)。结论缺氧可致新生儿心肌损害,心肌酶活性增高可提示新生儿缺氧。

Objective To investigate the dependablity of myocardium enzyme and hypoxia In neonatus, Methods The laboratory datas on the myocardium enzyme were analyzed by multiple linear regression related with hypoxia. Results compared with control group,the level of the myocardium enzyme increased significantly in study group（ P 〈 0. 01 ）, Conclusion Hypoxia can evoke myocardial damage, the heighten of the level on the myocardium enzyme can hint anoxia neonatorum.