摘要
目的了解干燥综合征(SS)重叠皮肌炎(DM)的临床特点。方法收集山西医科大学第二医院风湿科2004年1月至2007年11月收治的SS重叠DM患者10例,选择30例同期收治的性别、年龄相配的原发干燥综合征(pSS)患者为对照,从临床特点、实验室检查及预后等方面进行分析。结果SS/DM重叠组突出特点是内脏损害多且严重,肺损害尤为明显。该组发热、雷诺现象、皮疹、肺部损害、血液系统损害、抗Jo-1抗体阳性率和病死率高于pSS组,其他病情观察指标差异无统计学意义。结论SS/DM重叠综合征内脏损害重,进展快,病死率高,应尽早积极治疗。
Objective To explore the clinical features of Sjogren' s syndrome(SS) overlapping dermatomyositis(DM). Methods 10 cases of SS overlapping DM collected from January 2004 to November 2007 were investigated,30 primary Sjogren' s syndrome(pSS) cases hospitalized during the same period were chosen as the control group. The clinical characteristics, laboratory examinations and prognosis of the two groups were analyzed. Results Internal organs damages of the SS/DM group are more serious than the control group' s. Some aspects including fever,raynaud' s phenomenon, erythra, lung damage, hematological system damage, anti Jo-1 antibody and case-fatality of the SS/DM group has relatively higher rate than the control group' s. There are no statistical differences in other features. Conclusion The progress of Sjogren' s syndrome overlapping dermatomyositis with high mortality rate is fast,active treatment should be given as soon'as possible.
出处
《中国实用医药》
2008年第10期41-43,共3页
China Practical Medicine
关键词
干燥综合征
皮肌炎
重叠综合征
肺间质纤维化
Sjogren' s syndrome
Dermatomyositis
Overlap syndrome
Pulmonary interstitial fibrosis