2,5-二羟基苯磺酸钙对早期糖尿病肾病患者肾脏保护作用及血液流变学的影响

Effect of calcium dobesilate on renal and hemorheology in patients with early diabetic nephropathy

目的观察2,5-二羟基苯磺酸钙对早期糖尿病肾病(DN)患者的肾脏保护作用及血液流变学影响。方法将73例DN患者随机分成两组,A组用2,5-二羟基苯磺酸钙、B组用培哚普利,均治疗12周。比较两组疗效,以及治疗前后24 h尿白蛋白排出量(UAE)、血浆纤溶酶原激活物抑制剂1(PAI-1)、纤维蛋白原(Fib)、血液流变学等变化。结果治疗后,A组总有效率86.49%,B组86.11%;与治疗前比较,两组UAE均下降(P<0.01),以A组明显;两组血浆PAI-1均下降(P<0.05);与B组比较,A组全血黏度高切、中切1、中切2、低切,血浆黏度、Fib下降(P<0.05)。结论2,5-二羟基苯磺酸钙可降低早期DN患者的UAE及血浆PAI-1,改善血液流变学异常,延缓DN进展。

Objective To observe the effect of calcium dobesilate on renal and hemorheology in patients with early diabetic nephropathy （DN）. Methods 73 patients with early DN were divided into two groups. A group was treated with calcium dobesilate and B group was treated with perindopril for 12 weeks. Therapeutic effects of two groups, urinary albumin excretion （UAE） , plasminogen activator inhibitor-1 （ PAI-1 ） , fibrinogen （Fib） and hemorheology were compared before and after the treatment. Results After the treatment, the total effective rate was 86.49% in A group while 86.11% in B group; the level of UAE decreased in two groups （ P 〈 0.01 ）, especially in A group; the level of PAI-1 decreased in two groups（P 〈0. 05） ; blood viscosity, plasma viscosity and fibrinogen decreased in A group compared with B group. Conclusions In patients with early DN, calcium dobesilate can decrease the levels of UAE and PAI-1, improve hemorheology and postpone the development of DN.